Screening Test

Answer the following questions:

Define the following groups of terms:
Primary, secondary, and tertiary prevention
Prepathogenesis and pathogenesis
How does screening for disease align with the three levels of prevention – primary, secondary and tertiary?

Define the following terms that are related to screening tests:
Reliability and validity
Sensitivity and Specificity
Predictive value (+) and predictive value (-)
What are the most appropriate applications of mass screening and selective screening?  Give one example each of a mass screening test and a selective screening test.
How could screening performed in conjunction with disease surveillance contribute to the alleviation of work-related hazardous exposures?
What is meant by overdiagnosis?
Conduct a web search for “whole body scans”.  They are CT scans of the entire body and are promoted as a method for early detection of abnormalities.  Using your own ideas, construct a list of the advantages and disadvantages of whole body scans and reach a conclusion.  To what extent are whole body scans related to the issue of overdiagnosis?
Why is newborn screening important for public health practice?  Give examples of programs for newborn screening.
What is a method used for developmental screening?  At what ages is developmental screening most relevant?
Calculate the specificity, sensitivity, predictive value (+), and predictive value (-) using the following data: 

Disease Present

Disease Absent

Screening Test (+)



Screening Test (-)



Describe methods of screening for each of the following conditions:
Breast cancer
Colon cancer
Type 2 Diabetes
Elevated lipid levels
Genetic screening (BRCA gene)


The assignment must answer all the questions.
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